Adjuvant and neoadjuvant chemotherapy for osteosarcoma: JCOG Bone and Soft Tissue Tumor Study Group

Abstract The usefulness of adjuvant chemotherapy for high-grade osteosarcoma was established by two randomized, controlled trials conducted in the 1980s, which used six drugs, doxorubicin, cisplatin, high-dose methotrexate, bleomycin, cyclophosphamide and actinomycin D. Since then, development has been promoted direction introducing preoperative chemotherapy, changing post-operative according to histological effects, adding ifosfamide as a key drug strengthening chemotherapy. No clinical trials, however, have shown effectiveness study treatment, improvement treatment results during that time slight, although JCOG0905 is now going verify patients who experienced limited therapeutic effects. We are desperately looking breakthrough.